艾滋病患者及p24抗原血症的HIV-1感染患者血液中TcRγδ⁺淋巴细胞减少。
Decreased blood TcR gamma delta+ lymphocytes in AIDS and p24-antigenemic HIV-1-infected patients.
作者信息
Hermier F, Comby E, Delaunay A, Petitjean J, Favennec L, Bazin C, Freymuth F, Ballet J J
机构信息
Laboratory of Immunology and Immunopathology, CHRU Clémenceau, Caen, France.
出版信息
Clin Immunol Immunopathol. 1993 Nov;69(2):248-50. doi: 10.1006/clin.1993.1176.
The significance of blood TcR gamma delta+ lymphocyte level was evaluated in the context of immunodeficiency and infections in 209 HIV-1-infected patients. Blood TcR gamma delta+ lymphocyte values were found higher in patients belonging to the CDC group II/III than those in the CDC groups IV C1 and IV D (P < 0.001) and P < 0.01, respectively). TcR gamma delta+ lymphocyte counts were lower in patients with oral candidiasis (P < 0.01), and in association with pneumocystosis or toxoplasmosis (P < 0.001). In 81 patients with a detectable HIV-1 p24 antigenemia, TcR gamma delta+ lymphocyte counts were lower than those in nonantigenemic patients (P < 0.001). In the CDC II/III group, p24-antigenemic patients exhibited lower TcR gamma delta+ cell counts than those in patients without antigenemia (P = 0.06). Data suggest that depletion of the TcR gamma delta+ lymphocyte subset characterizes HIV-1-infected patients with oral candidiasis, pneumocystosis, toxoplasmosis, and/or HIV-1-antigenemia.
在209例HIV-1感染患者中，在免疫缺陷和感染背景下评估了血液中TcRγδ+淋巴细胞水平的意义。发现疾病控制中心（CDC）II/III组患者的血液TcRγδ+淋巴细胞值高于CDC IV C1组和IV D组患者，差异分别具有统计学意义（P<0.001）和P<0.01。口腔念珠菌病患者的TcRγδ+淋巴细胞计数较低（P<0.01），并且与肺孢子菌病或弓形虫病相关时也较低（P<0.001）。在81例可检测到HIV-1 p24抗原血症的患者中，TcRγδ+淋巴细胞计数低于无抗原血症的患者（P<0.001）。在CDC II/III组中，有p24抗原血症的患者的TcRγδ+细胞计数低于无抗原血症的患者（P = 0.06）。数据表明，TcRγδ+淋巴细胞亚群的耗竭是患有口腔念珠菌病、肺孢子菌病、弓形虫病和/或HIV-1抗原血症的HIV-1感染患者的特征。
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