人类22号染色体上编码白血病抑制因子（LIF）和抑瘤素M（OSM）的基因串联连接。
Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.
作者信息
Giovannini M, Djabali M, McElligott D, Selleri L, Evans G A
机构信息
Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92138.
出版信息
Cytogenet Cell Genet. 1993;64(3-4):240-4. doi: 10.1159/000133586.
Leukemia-inhibitory factor (LIF) and oncostatin M (OSM) are members of a family of structurally similar growth factors presenting overlapping and specific functions. Although the genes coding for IL-6, CSF3 and CNTF are scattered in the human and mouse genome, human LIF and OSM genes have conserved synteny in the course of evolution. Through isolation of a YAC and a cosmid clone containing both LIF and OSM we demonstrate that the two genes are linked in tandem on human chromosome 22q12, separated by 16 kilobases of intervening genomic DNA and transcribed in the same head-to-tail orientation. The close physical linkage between LIF and OSM genes brings new evidence of their evolutionary relationship.
白血病抑制因子（LIF）和抑瘤素M（OSM）是一类结构相似的生长因子家族成员，具有重叠和特定的功能。尽管编码IL-6、CSF3和CNTF的基因分散在人类和小鼠基因组中，但人类LIF和OSM基因在进化过程中具有保守的同线性。通过分离包含LIF和OSM的酵母人工染色体（YAC）和黏粒克隆，我们证明这两个基因在人类22号染色体q12上串联相连，中间间隔16千碱基的基因组DNA，并以相同的头对头方向转录。LIF和OSM基因之间紧密的物理连接为它们的进化关系提供了新证据。
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