Giovannini M, Selleri L, Hermanson G G, Evans G A
Molecular Genetics Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138-9216.
Cytogenet Cell Genet. 1993;62(1):32-4. doi: 10.1159/000133439.
Using fluorescence in situ hybridization, a cosmid clone containing the gene for oncostatin M (OSM) was mapped to human chromosome 22q12, placing the OSM gene in the same chromosome band as the leukemia-inhibitory factor gene (LIF). The location of the OSM gene was determined relative to the t(11;22)(q24;q12) of Ewing's sarcoma and found to be distal to the translocation breakpoint on chromosome 22. Analysis of physical distances by pulsed-field gel electrophoresis demonstrated further that the two genes lie within 500 kb of each other.
