Weiss W
Department of Medicine, Hahnemann University, Philadelphia.
Chest. 1993 Jun;103(6):1854-9. doi: 10.1378/chest.103.6.1854.
The English-language literature was reviewed to evaluate a possible relationship between asbestos-related pleural plaques and lung cancer in the absence of parenchymal asbestosis. There were six cohort studies in which the comparison group was limited to unexposed persons or the general population, four lung cancer case-control studies, and three autopsy studies. Of the 13 investigations, only 3 supported the hypothesis that lung cancer risk is elevated among persons with pleural plaques over the risk in unexposed people: 2 cohort studies from the same city in England with much the same data and 1 case-control study. These three studies had the most defects in design. The other ten studies failed to confirm the hypothesis. Thus, the weight of the evidence favors the conclusion that persons with asbestos-related pleural plaques do not have an increased risk of lung cancer in the absence of parenchymal asbestosis.
对英文文献进行了综述，以评估在无实质性石棉肺的情况下，石棉相关胸膜斑与肺癌之间可能存在的关系。有六项队列研究，其中对照组仅限于未接触者或普通人群，四项肺癌病例对照研究，以及三项尸检研究。在这13项调查中，只有3项支持以下假设：有胸膜斑的人患肺癌的风险高于未接触者：两项来自英国同一城市、数据大致相同的队列研究，以及一项病例对照研究。这三项研究在设计上存在最多缺陷。其他十项研究未能证实该假设。因此，证据的权重支持以下结论：在无实质性石棉肺的情况下，有石棉相关胸膜斑的人患肺癌的风险不会增加。
