Lazzarin M, Ferrari S
Minerva Med. 1977 Feb 21;68(4):229-34.
The effect of oral clonidine on prothrombin time, partial thromboplastin time, blood fibrinogen, fibrinolytic activity and platelet count was investigated in 25 hypertensive and 7 normal subjects. High plasma fibrinogen levels were present in 80% of the hypertensive patients and prolonged lysis time in 28%; the means values were 487 +/- 135 mg % and 223 +/- 62 min., respectively. The other coagulation tests were normal. 0,300-0,450 mg/day clonidine per os for 15 days both decreased fibginogen levels (mean 406 +/- 149; p less than 0.05) and shortened lysis time (mean 153 +/- 78 min; p less than 0.005). No changes were noted in the normal subjects. The pathophysiological mechanism of these findings is discussed and their possible implications for the treatment of hypertension are emphasised.
对25名高血压患者和7名正常受试者研究了口服可乐定对凝血酶原时间、部分凝血活酶时间、血浆纤维蛋白原、纤溶活性及血小板计数的影响。80%的高血压患者血浆纤维蛋白原水平升高，28%的患者纤溶时间延长；均值分别为487±135mg%和223±62分钟。其他凝血试验均正常。每日口服0.300 - 0.450mg可乐定，共15天，可使纤维蛋白原水平降低（均值406±149；p<0.05），并缩短纤溶时间（均值153±78分钟；p<0.005）。正常受试者未见变化。讨论了这些发现的病理生理机制，并强调了其对高血压治疗的可能意义。
