Smythe W R, Bavaria J E
Department of General, University of Pennsylvania School of Medicine, Philadelphia.
Chest. 1993 Oct;104(4):1274-6. doi: 10.1378/chest.104.4.1274.
Chemical pleurodesis is a frequently performed procedure for pneumothorax and effusion and significant adverse effects are unusual. We present a previously unreported case of acute renal failure associated with tetracycline pleurodesis. Recent studies have shown that intrapleural drug administration may lead to therapeutic serum levels. Systemic toxic drug effects may therefore be noted with chemical pleurodesants such as tetracycline. Alternative methods of pleurodesis should always be considered if a sensitivity or metabolic abnormality is suspected.
化学性胸膜固定术是治疗气胸和胸腔积液的常用方法，严重不良反应并不常见。我们报告一例此前未报道的与四环素胸膜固定术相关的急性肾衰竭病例。近期研究表明，胸腔内给药可能会使血清达到治疗水平。因此，使用四环素等化学性胸膜固定剂时可能会出现全身毒性药物反应。如果怀疑有药物敏感性或代谢异常，应始终考虑采用其他胸膜固定方法。
