Worthington D, Maloney A H, Smith B T
Obstet Gynecol. 1977 Mar;49(3):275-9.
In a prospective study of 133 spontaneous premature deliveries the relation between premature rupture of the membranes (PRM) and development of respiratory distress syndrome (RDS) in newborn infants is examined. PRM is associated with a significantly decreased incidence of RDS in newborn infants (P less than 0.002). This relation is valid at a gestational age of 28 weeks or more and a birthweight greater than 1000 g. Total respiratory morbidity in newborn infants (transient tachypnea + RDS) is also significantly decreased when labor is associated with PRM (P less than 0.005). Assessment of the influences of sex of the infant, fetal asphyxia, and delivery by cesarian section shows that PRM bears a stronger relation than each of these individual factors to a decreased incidence of RDS. Duration of the latent period has no influence on protection from RDS, and it is suggested that fetal lung maturity occurs before the membranes rupture.
在一项对133例自然早产的前瞻性研究中，对胎膜早破（PRM）与新生儿呼吸窘迫综合征（RDS）的发生之间的关系进行了研究。PRM与新生儿RDS的发生率显著降低相关（P<0.002）。这种关系在孕龄28周及以上且出生体重超过1000克时成立。当分娩与PRM相关时，新生儿的总呼吸发病率（短暂性呼吸急促+RDS）也显著降低（P<0.005）。对婴儿性别、胎儿窒息和剖宫产分娩的影响进行评估表明，PRM与RDS发病率降低的关系比这些个体因素中的每一个都更强。潜伏期的长短对预防RDS没有影响，提示胎儿肺成熟发生在胎膜破裂之前。
