Majane E A, Zhu J, Aarnisalo A A, Panula P, Yang H Y
Laboratory of Biochemical Genetics, National Institute of Mental Health Neuroscience Center, St. Elizabeth's Hospital, Washington, D.C. 20032.
Endocrinology. 1993 Oct;133(4):1578-84. doi: 10.1210/endo.133.4.8404597.
Neuropeptide-FF (FLFQPQRF-NH2), originally isolated from bovine brain, is an FMRF-NH2-like peptide with morphine-modulating activity. Neuropeptide-FF (NPFF) is unevenly distributed in the central nervous system, with the highest concentrations in posterior pituitary and spinal cord. In the rat pituitary, NPFF is found exclusively in the neural lobe, where it is localized in nerve terminals and fibers, indicating the hypothalamus as a possible source of the neural lobe NPFF. In this study the origin of neurohypophyseal NPFF was investigated using various hypothalamic lesions and an anterograde tracing experiment. The results suggest that at least part of the neurohypophyseal NPFF originates from the supraoptic nucleus and may be localized in some of the arginine vasopressin-containing magnocellular neurons.
神经肽FF（FLFQPQRF-NH2）最初是从牛脑中分离出来的，是一种具有吗啡调节活性的类FMRF-NH2肽。神经肽FF（NPFF）在中枢神经系统中分布不均，在后叶垂体和脊髓中浓度最高。在大鼠垂体中，NPFF仅存在于神经叶中，位于神经末梢和纤维中，表明下丘脑可能是神经叶NPFF的来源。在本研究中，使用各种下丘脑损伤和顺行追踪实验研究了神经垂体NPFF的起源。结果表明，神经垂体NPFF至少部分起源于视上核，并且可能定位于一些含精氨酸加压素的大细胞神经元中。
