Majane E A, Yang H Y
Laboratory of Biochemical Genetics, NIMH Neuroscience Center, St. Elizabeths, Washington, DC 20032.
Peptides. 1991 Nov-Dec;12(6):1303-8. doi: 10.1016/0196-9781(91)90211-7.
Previous studies with the Brattleboro rat suggested a possible interaction at the pituitary level between AVP and the neuropeptide, F-8-F-NH2. In order to test this hypothesis, we studied the effect of various osmotic stimuli on neurohypophyseal F-8-F-NH2. In rats drinking 2% NaCl solution for two days, neural lobe AVP and F-8-F-NH2 levels were equally reduced by 87%. After maximal depletion, pituitary levels of F-8-F-NH2 and AVP rebounded in parallel when normal drinking water was reintroduced. Pituitary stalk transection depleted neurohypophyseal F-8-F-NH2. The results of this study suggest that neurohypophyseal F-8-F-NH2 originates from the hypothalamus and, furthermore, is coreleased along with AVP in response to hyperosmotic stimuli.
先前对布拉特洛维大鼠的研究表明，抗利尿激素（AVP）与神经肽F-8-F-NH2在垂体水平可能存在相互作用。为了验证这一假设，我们研究了各种渗透压刺激对神经垂体F-8-F-NH2的影响。在饮用2%氯化钠溶液两天的大鼠中，神经叶抗利尿激素和F-8-F-NH2水平均同等程度降低了87%。在最大程度耗竭后，重新引入正常饮用水时，垂体中F-8-F-NH2和抗利尿激素水平平行回升。垂体柄横断使神经垂体F-8-F-NH2耗竭。本研究结果表明，神经垂体F-8-F-NH2起源于下丘脑，此外，在高渗刺激下，它与抗利尿激素一同被释放。
