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Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations.

作者信息

Reviriego J, Bertilsson L, Carrillo J A, Llerena A, Valdivielso M J, Benítez J

机构信息

Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Spain.

出版信息

Eur J Clin Pharmacol. 1993;44(6):593-5. doi: 10.1007/BF02440867.

DOI:10.1007/BF02440867
PMID:8405020
Abstract

We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, healthy Spanish Caucasian subjects, based on the enantiomeric S/R mephenytoin ratio in urine collected 0-8 h and 24-32 h after intake of the racemic drug. Five of the subjects were PM (1.34%, 95% confidence interval 0.18-2.59%), a prevalence lower than in 6 other Caucasian populations, but only significantly lower than in studies in France and Switzerland (P < 0.01). We suggest that this difference might be due to the use of different phenotyping procedures.

摘要

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Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism.高加索人中美芬妥英羟化缺乏症：一种新的氧化药物代谢多态性的频率
Clin Pharmacol Ther. 1984 Dec;36(6):773-80. doi: 10.1038/clpt.1984.256.
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Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations.日本人群与白种人群之间在异喹胍和甲妥英羟基化遗传多态性上的种族差异。
Clin Pharmacol Ther. 1985 Oct;38(4):402-8. doi: 10.1038/clpt.1985.194.
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Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital.美芬妥因在人体内的多态性代谢：与共同调节底物美索比妥的药代动力学相互作用。
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Phenotyping polymorphic drug metabolism in the French Caucasian population.对法国白种人群中多态性药物代谢进行表型分析。
Eur J Clin Pharmacol. 1988;35(2):167-71. doi: 10.1007/BF00609247.
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Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities.
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