维生素B6缺乏会导致大鼠肝脏中RNA聚合酶的激活以及基因表达的普遍增强。
Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver.
作者信息
Oka T, Komori N, Kuwahata M, Sassa T, Suzuki I, Okada M, Natori Y
机构信息
Department of Nutrition, School of Medicine, University of Tokushima, Japan.
出版信息
FEBS Lett. 1993 Sep 27;331(1-2):162-4. doi: 10.1016/0014-5793(93)80318-o.
The effect of vitamin B6 deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B6-deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for beta-actin and glyceraldehyde-3-phosphate dehydrogenase, and the content of poly(A)+ RNA were also increased in vitamin deficiency. These observations suggest that vitamin B6 influences gene expression in the liver, at least in part, by modulating the activity of RNA polymerase.
研究了维生素B6缺乏对大鼠肝脏RNA聚合酶活性和几种mRNA表达的影响。发现维生素B6缺乏大鼠肝脏中RNA聚合酶I和II的活性比对照大鼠高30%。在维生素缺乏的情况下，包括β-肌动蛋白和甘油醛-3-磷酸脱氢酶的mRNA在内的几种mRNA的表达以及聚腺苷酸（poly(A)+）RNA的含量也增加了。这些观察结果表明，维生素B6至少部分地通过调节RNA聚合酶的活性来影响肝脏中的基因表达。
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