Canonico P L, Sortino M A, Favit A, Aleppo G, Scapagnini U
University of Pavia School of Dentistry, Italy.
Funct Neurol. 1993 May-Jun;8(3):183-8.
The effect of dihydroergocryptine, a natural alkaloid derivative which exhibits D2 dopaminomimetic properties, has been studied in Lewis female rats with experimentally induced allergic encephalomyelitis. A chronic treatment with dihydroergocryptine started two days before immunization, induced a dramatic reduction of prolactin levels accompanied by a marked amelioration of neurological signs. In addition, the proliferative activity of splenic lymphocytes induced by the mitogen Concanavalin-A (Con-A) was reduced in dihydroergocryptine-treated animals. It is suggested that this effect is related to the ability of dihydroergocryptine to lower prolactin concentrations or also, partially, to a neuroprotective action of this drug.
已在实验性诱发变应性脑脊髓炎的Lewis雌性大鼠中研究了二氢麦角隐亭（一种具有D2多巴胺模拟特性的天然生物碱衍生物）的作用。在免疫前两天开始用二氢麦角隐亭进行慢性治疗，可使催乳素水平显著降低，并伴有神经症状的明显改善。此外，在接受二氢麦角隐亭治疗的动物中，由促有丝分裂剂刀豆球蛋白A（Con-A）诱导的脾淋巴细胞增殖活性降低。提示这种作用与二氢麦角隐亭降低催乳素浓度的能力有关，也可能部分与该药物的神经保护作用有关。
