Okabe S, Miyake H
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Nihon Yakurigaku Zasshi. 1993 Sep;102(3):235-44. doi: 10.1254/fpj.102.235.
This review article describes the effect and mechanism of various antisecretory drugs. Both histamine H2-receptor antagonists and gastric proton pump inhibitors are now world-widely used as the first choice for the treatment of acid-related diseases. Because of their potential effectiveness in inhibiting gastric acid secretion, new H2-antagonists and pump inhibitors are under development with the aim of mitigating of the side effects. The local antisecretory effects of FPL-52694, NC-1300-O-3 and ME 3407, which were demonstrated in Heidenhain pouch dogs, will provide clues for the development of new types of antisecretory drugs. Antigastrin drugs are also promising.
这篇综述文章描述了各种抗分泌药物的作用和机制。组胺H2受体拮抗剂和胃质子泵抑制剂目前在世界范围内都被用作治疗酸相关性疾病的首选药物。由于它们在抑制胃酸分泌方面具有潜在疗效，新型H2拮抗剂和质子泵抑制剂正在研发中，目的是减轻副作用。在海登海因小胃犬身上证实的FPL-52694、NC-1300-O-3和ME 3407的局部抗分泌作用，将为新型抗分泌药物的研发提供线索。抗胃泌素药物也很有前景。
