Pedreira J D, Guardia J, Benet J M, Martin C, Esteban R, Martinez-Vazquez J M, Bacardi R
Nouv Presse Med. 1977 Feb 19;6(7):544-6.
The histological lesions found in patients with hepatic disease and positive anti-mitochondrial antibodies (AMA) by immunofluorescence were compared with those in 10 subjects of the same age and sex with negative AMA. The majority of the patients with positive AMA were suffering from primary biliary cirrhosis, the diagnosis being based upon the histological appearance (Stage 1 of Scheuer's classification: 40%) or the presence of clinical signs of cholestasis with a compatible histological appearance (40%). None of the remaining patients (20%) with positive AMA nor the 10 individuals with negative AMA showed histological signs suggestive of primary biliary cirrhosis. The absence of certain clinico-biological factors, with the exception of Stage 1 histology, gives a high degree of value to a high level of AMA in the diagnostic of PBC.
通过免疫荧光法对肝病患者且抗线粒体抗体（AMA）呈阳性者的组织学病变，与10名年龄和性别相同但AMA呈阴性的受试者的组织学病变进行了比较。大多数AMA呈阳性的患者患有原发性胆汁性肝硬化，诊断依据组织学表现（Scheuer分类的1期：40%）或存在胆汁淤积的临床体征且伴有相符的组织学表现（40%）。其余AMA呈阳性的患者（20%）以及10名AMA呈阴性的个体均未表现出提示原发性胆汁性肝硬化的组织学体征。除了1期组织学外，某些临床生物学因素的缺失使得高水平的AMA在原发性胆汁性肝硬化的诊断中具有很高的价值。
