抗体介导增强嗜肺军团菌诱导的白细胞介素1活性。
Antibody-mediated enhancement of Legionella pneumophila-induced interleukin 1 activity.
作者信息
Widen R H, Newton C A, Klein T W, Friedman H
机构信息
Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa 33612-4799.
出版信息
Infect Immun. 1993 Oct;61(10):4027-32. doi: 10.1128/iai.61.10.4027-4032.1993.
Abstract
The ability of antibody specific for Legionella pneumophila to enhance the induction of interleukin 1 (IL-1) production by murine peritoneal, splenic, and pulmonary macrophages in response to the bacterium was examined. Two preparations of L. pneumophila were utilized, a formalin-killed whole-cell preparation and viable bacteria. We measured both secreted (sIL-1) and cell membrane-associated (mIL-1) activities after incubation of the macrophages with the bacterial preparations in the presence or absence of the antibody. Both bacterial preparations induced sIL-1 and mIL-1 activities in each of the macrophage populations tested. These activities were generally enhanced by pretreating the bacteria with antibody, with the greatest enhancing activity observed for the formalin-killed preparations at lower doses of bacteria.
摘要
研究了抗嗜肺军团菌抗体增强小鼠腹腔、脾脏和肺巨噬细胞对该细菌应答诱导白细胞介素1（IL-1）产生的能力。使用了两种嗜肺军团菌制剂，一种是福尔马林灭活的全细胞制剂和活细菌。在有或没有抗体存在的情况下，将巨噬细胞与细菌制剂孵育后，我们测量了分泌型（sIL-1）和细胞膜相关型（mIL-1）活性。两种细菌制剂在每个测试的巨噬细胞群体中均诱导了sIL-1和mIL-1活性。通过用抗体预处理细菌，这些活性通常会增强，在较低剂量细菌时，福尔马林灭活制剂观察到最大的增强活性。
相似文献
1
Antibody-mediated enhancement of Legionella pneumophila-induced interleukin 1 activity.抗体介导增强嗜肺军团菌诱导的白细胞介素1活性。
Infect Immun. 1993 Oct;61(10):4027-32. doi: 10.1128/iai.61.10.4027-4032.1993.
2
Induction of interleukin 1 by Legionella pneumophila in murine peritoneal macrophage cultures.嗜肺军团菌在小鼠腹腔巨噬细胞培养物中诱导白细胞介素1的产生。
Proc Soc Exp Biol Med. 1989 Jul;191(3):304-8. doi: 10.3181/00379727-191-42925.
3
Dendritic cells pulsed with live and dead Legionella pneumophila elicit distinct immune responses.用活的和死的嗜肺军团菌脉冲处理的树突状细胞引发不同的免疫反应。
J Immunol. 2004 Feb 1;172(3):1727-34. doi: 10.4049/jimmunol.172.3.1727.
4
Humoral immunity and regulation of intrapulmonary growth of Legionella pneumophila in the immunocompetent host.体液免疫与免疫功能正常宿主中嗜肺军团菌肺内生长的调节
J Immunol. 1996 Dec 1;157(11):5002-8.
5
Murine macrophages differentially produce proinflammatory cytokines after infection with virulent vs. avirulent Legionella pneumophila.用有毒力与无毒力的嗜肺军团菌感染小鼠巨噬细胞后，它们会产生不同的促炎细胞因子。
J Leukoc Biol. 2000 Jun;67(6):863-8. doi: 10.1002/jlb.67.6.863.
6
Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice.Toll样受体9在嗜肺军团菌诱导的来自易感和非易感小鼠骨髓来源的树突状细胞和巨噬细胞中白细胞介素-12 p40产生中的作用
Infect Immun. 2007 Jan;75(1):146-51. doi: 10.1128/IAI.01011-06. Epub 2006 Oct 23.
7
Alveolar macrophage cell line MH-S is valuable as an in vitro model for Legionella pneumophila infection.肺泡巨噬细胞系MH-S作为嗜肺军团菌感染的体外模型具有重要价值。
Am J Respir Cell Mol Biol. 2001 Mar;24(3):326-31. doi: 10.1165/ajrcmb.24.3.4359.
8
Differential effects of granulocyte/macrophage colony-stimulating factor (GM-CSF) in enhancing macrophage resistance to Legionella pneumophila vs Candida albicans.粒细胞/巨噬细胞集落刺激因子（GM-CSF）在增强巨噬细胞对嗜肺军团菌和白色念珠菌抵抗力方面的差异作用。
Cell Immunol. 1997 Feb 25;176(1):75-81. doi: 10.1006/cimm.1996.1074.
9
Investigation of the role of macrophages and endogenous interferon-gamma in natural resistance of mice against Legionella pneumophila infection.巨噬细胞和内源性干扰素-γ在小鼠对嗜肺军团菌感染的天然抵抗力中的作用研究。
FEMS Microbiol Immunol. 1992 Apr;4(4):183-91. doi: 10.1111/j.1574-6968.1992.tb04993.x.
10
Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila.Toll样受体2和4在巨噬细胞对嗜肺军团菌体外反应中的不同作用
Infect Immun. 2005 Jan;73(1):352-61. doi: 10.1128/IAI.73.1.352-361.2005.
引用本文的文献
1
Antigen specificity shapes antibody functions in tuberculosis.抗原特异性塑造了结核病中抗体的功能。
bioRxiv. 2024 Jul 2:2024.06.03.597169. doi: 10.1101/2024.06.03.597169.
2
New concepts in antibody-mediated immunity.抗体介导免疫的新概念。
Infect Immun. 2004 Nov;72(11):6191-6. doi: 10.1128/IAI.72.11.6191-6196.2004.
3
Binding of Legionella pneumophila to macrophages increases cellular cytokine mRNA.嗜肺军团菌与巨噬细胞的结合会增加细胞细胞因子信使核糖核酸。
Infect Immun. 1994 Sep;62(9):3947-56. doi: 10.1128/iai.62.9.3947-3956.1994.
4
Quantitative reverse transcription-PCR analysis of Legionella pneumophila-induced cytokine mRNA in different macrophage populations by high-performance liquid chromatography.通过高效液相色谱法对不同巨噬细胞群体中嗜肺军团菌诱导的细胞因子mRNA进行定量逆转录-聚合酶链反应分析。
Clin Diagn Lab Immunol. 1995 Jan;2(1):18-24. doi: 10.1128/cdli.2.1.18-24.1995.
本文引用的文献
1
Sporadic legionellosis in the United States: the first thousand cases.美国的散发性军团病：最初的一千例病例
Ann Intern Med. 1981 Feb;94(2):164-70. doi: 10.7326/0003-4819-94-2-164.
2
Activated human monocytes inhibit the intracellular multiplication of Legionnaires' disease bacteria.活化的人类单核细胞可抑制军团病杆菌的细胞内增殖。
J Exp Med. 1981 Nov 1;154(5):1618-35. doi: 10.1084/jem.154.5.1618.
3
The prevalence of serum antibodies to Legionella pneumophila in patients with chronic pulmonary disease.慢性肺部疾病患者中嗜肺军团菌血清抗体的患病率。
Am Rev Respir Dis. 1981 Feb;123(2):238-9. doi: 10.1164/arrd.1981.123.2.238.
4
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.军团菌病细菌（嗜肺军团菌）在人类单核细胞内进行细胞内增殖。
J Clin Invest. 1980 Sep;66(3):441-50. doi: 10.1172/JCI109874.
5
Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody, and complement.军团病细菌（嗜肺军团菌）与人类吞噬细胞的相互作用。I. 嗜肺军团菌抵抗多形核白细胞、抗体和补体的杀伤作用。
J Exp Med. 1981 Feb 1;153(2):386-97. doi: 10.1084/jem.153.2.386.
6
Validation of Legionella pneumophila indirect immunofluorescence assay with epidemic sera.嗜肺军团菌间接免疫荧光检测法在流行性血清中的验证
J Clin Microbiol. 1981 Jan;13(1):139-46. doi: 10.1128/jcm.13.1.139-146.1981.
7
Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors.人C5a与巨噬细胞表面C5a受体结合诱导白细胞介素1分泌并增强体液免疫。
J Exp Med. 1982 Sep 1;156(3):912-7. doi: 10.1084/jem.156.3.912.
8
Legionella pneumophila-induced blastogenesis of murine lymphoid cells in vitro.嗜肺军团菌在体外诱导小鼠淋巴细胞增殖。
Infect Immun. 1984 Jan;43(1):314-9. doi: 10.1128/iai.43.1.314-319.1984.
9
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.小鼠白细胞介素-1 cDNA在大肠杆菌中的克隆与表达。
Nature. 1984;312(5993):458-62. doi: 10.1038/312458a0.
10
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.人单核细胞白细胞介素-1前体cDNA的核苷酸序列
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7907-11. doi: 10.1073/pnas.81.24.7907.
Zotero 插件