Chapman B L, Hendrick M J, Washabau R J
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
J Am Vet Med Assoc. 1993 Sep 1;203(5):680-4.
Granulomatous hepatitis (GH) is an uncommon histopathologic diagnosis in dogs. On the basis of clinical reports, fungal infections appear to be the most common cause of GH in dogs, but many other potential causes have been identified. The medical records and histopathologic findings for 9 dogs with GH were reviewed to identify additional specific causes of GH in dogs. Diseases associated with GH included intestinal lymphangiectasia (n = 2), lymphosarcoma (n = 1), histiocytosis (n = 1), dirofilariasis (n = 1), and histoplasmosis (n = 1). In 1 dog, no other disease process was identified. Of the remaining 2 dogs, 1 had concurrent granulomatous pneumonitis of unknown cause, and the other had periportal hepatitis and temporal muscle wasting. All 9 dogs with GH had clinical evidence of liver disease, such as hepatomegaly, icterus, and ascites, or had high serum alkaline phosphatase and alanine aminotransferase activity. Because of the wide variety of potential causes of GH in dogs, an accurate diagnosis should be sought so that appropriate treatment can be chosen and an accurate prognosis given.
肉芽肿性肝炎（GH）在犬类中是一种不常见的组织病理学诊断。根据临床报告，真菌感染似乎是犬类GH最常见的病因，但已确定许多其他潜在病因。回顾了9只患有GH的犬的病历和组织病理学检查结果，以确定犬类GH的其他特定病因。与GH相关的疾病包括肠淋巴管扩张症（n = 2）、淋巴肉瘤（n = 1）、组织细胞增多症（n = 1）、恶丝虫病（n = 1）和组织胞浆菌病（n = 1）。1只犬未发现其他疾病过程。其余2只犬中，1只同时患有病因不明的肉芽肿性肺炎，另1只患有门静脉周围肝炎和颞肌萎缩。所有9只患有GH的犬都有肝病的临床证据，如肝肿大、黄疸和腹水，或血清碱性磷酸酶和丙氨酸转氨酶活性升高。由于犬类GH的潜在病因多种多样，应寻求准确的诊断，以便选择合适的治疗方法并给出准确的预后。
