通过向成年WKA大鼠静脉注射产生HTLV-1的兔或人T细胞系建立HTLV-1相关脊髓病/热带痉挛性截瘫样大鼠模型。
HTLV-1-associated myelopathy/tropical spastic paraparesis-like rats by intravenous injection of HTLV-1-producing rabbit or human T-cell line into adult WKA rats.
作者信息
Kushida S, Matsumura M, Tanaka H, Ami Y, Hori M, Kobayashi M, Uchida K, Yagami K, Kameyama T, Yoshizawa T
机构信息
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki.
出版信息
Jpn J Cancer Res. 1993 Aug;84(8):831-3. doi: 10.1111/j.1349-7006.1993.tb02052.x.
Abstract
We intravenously injected Ra-1 cells or MT-2 cells into female adult WKA rats. Spastic paraparesis mainly in the hind-limbs was observed in 1 out of 2 Ra-1 cell-injected WKA rats and in 3 out of 8 MT-2 cell-injected WKA rats 20-27 months after injection. The main neuropathological finding was symmetrical white matter degeneration with mononuclear cell infiltration of the spinal cord, similar to that of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, and degeneration of nerve roots and peripheral nerves. Antibodies against HTLV-1 antigens were detected in plasma and cerebrospinal fluid from these HAM/TSP-like rats. HTLV-1 provirus was detected from the peripheral blood mononuclear cells of one of these rats 20 months after injection. Interestingly, spastic paraparesis was not observed in F344 rats.
摘要
我们将Ra-1细胞或MT-2细胞静脉注射到成年雌性WKA大鼠体内。在注射后20 - 27个月，2只注射Ra-1细胞的WKA大鼠中有1只、8只注射MT-2细胞的WKA大鼠中有3只出现了主要累及后肢的痉挛性轻截瘫。主要神经病理学发现为脊髓对称性白质变性伴单核细胞浸润，类似于人类嗜T细胞病毒1型相关脊髓病/热带痉挛性轻截瘫（HAM/TSP）患者，同时神经根和周围神经也发生变性。在这些类似HAM/TSP的大鼠的血浆和脑脊液中检测到了抗HTLV-1抗原的抗体。在其中一只大鼠注射后20个月，从其外周血单核细胞中检测到了HTLV-1前病毒。有趣的是，在F344大鼠中未观察到痉挛性轻截瘫。
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