Doss S A, Tillotson G S, Amyes S G
Department of Medical Microbiology, Medical School, University of Edinburgh, UK.
J Appl Bacteriol. 1993 Aug;75(2):123-8. doi: 10.1111/j.1365-2672.1993.tb02756.x.
The production of virulence factors by various bacteria can be influenced by sub-inhibitory concentrations of antibiotics. The effect of six antibiotics on the production of representative extracellular enzymes and toxins produced by Staphylococcus aureus was investigated. The production of the virulence determinants coagulase, protein A, alpha and delta haemolysin was monitored in the presence of ciprofloxacin, enoxacin, chloramphenicol, gentamicin, tetracycline and methicillin. The protein synthesis inhibitors reduced the production of coagulase and protein A, and almost completely inhibited the production of the haemolysins. Haemolysin production was also reduced by ciprofloxacin and enoxacin, but these antibiotics had little effect on the production of coagulase and protein A. Methicillin stimulated the production of alpha and delta haemolysins but had no effect on the production of coagulase and protein A.
各种细菌毒力因子的产生会受到亚抑菌浓度抗生素的影响。研究了六种抗生素对金黄色葡萄球菌产生代表性细胞外酶和毒素的影响。在环丙沙星、依诺沙星、氯霉素、庆大霉素、四环素和甲氧西林存在的情况下，监测了毒力决定因子凝固酶、蛋白A、α和δ溶血素的产生。蛋白质合成抑制剂减少了凝固酶和蛋白A的产生，几乎完全抑制了溶血素的产生。环丙沙星和依诺沙星也降低了溶血素的产生，但这些抗生素对凝固酶和蛋白A的产生影响不大。甲氧西林刺激了α和δ溶血素的产生，但对凝固酶和蛋白A的产生没有影响。
