Moneib N A, Shibl A M, el-Said M A, el-Masry E M
Division of Microbiology, King Saud University, Riyadh, Saudi Arabi.
J Chemother. 1993 Oct;5(5):289-92. doi: 10.1080/1120009x.1993.11739246.
The effect of sub-MICs of azithromycin, clarithromycin and roxithromycin, as compared to erythromycin, on the production of coagulase, beta-hemolysin, lecithinase and deoxyribonuclease by Staphylococcus aureus was studied. All new macrolides completely inhibited coagulase and beta-hemolysin production and partially inhibited lecithinase and deoxyribonuclease. Such inhibition is not related either to growth inhibition or to inhibition of enzyme activity. Erythromycin, on the other hand, had no effect on coagulase or beta-hemolysin production but slightly suppressed the production of lecithinase and deoxyribonuclease. This inhibitory effect might have clinical significance if it was found to occur in vivo.
研究了与红霉素相比，阿奇霉素、克拉霉素和罗红霉素的亚抑菌浓度对金黄色葡萄球菌凝固酶、β-溶血素、卵磷脂酶和脱氧核糖核酸酶产生的影响。所有新型大环内酯类药物完全抑制凝固酶和β-溶血素的产生，并部分抑制卵磷脂酶和脱氧核糖核酸酶。这种抑制作用与生长抑制或酶活性抑制均无关。另一方面，红霉素对凝固酶或β-溶血素的产生没有影响，但略微抑制了卵磷脂酶和脱氧核糖核酸酶的产生。如果在体内发现这种抑制作用，可能具有临床意义。
