Remorgida V, Giordano M, Lanera P, Costantini S, de Cecco L
Istituto di Ginecologia ed Ostetricia, Universitá di Genova, Ospedale San Martino, Italy.
Hum Reprod. 1993 Jul;8(7):1001-4. doi: 10.1093/oxfordjournals.humrep.a138182.
The aim of this study was to evaluate the plasma absorption of i.m. administered exogenous urinary follicle stimulating hormone (FSH) in relation to body fatness, leanness and cell mass. Body composition was measured by means of bioelectrical impedance. An immunoradiometric assay was used to assess the concentration of exogenous FSH in blood in patients with a pharmacologically induced hypogonadotrophism who were undergoing ovulation induction for assisted reproduction. No correlation was found between body composition and the hormone concentration in blood. According to our results, the different requirements of gonadotrophin administration typically observed in patients of different weights are probably not related to different absorption and distribution of the drug.
本研究旨在评估肌肉注射外源性尿促卵泡素（FSH）的血浆吸收情况与身体脂肪、瘦体重和细胞质量之间的关系。通过生物电阻抗法测量身体成分。采用免疫放射分析法评估因药物诱导性腺功能减退而接受辅助生殖促排卵治疗的患者血液中外源性FSH的浓度。未发现身体成分与血液中激素浓度之间存在相关性。根据我们的研究结果，不同体重患者中通常观察到的促性腺激素给药需求差异可能与药物的不同吸收和分布无关。
