Akpınar Funda, Demir Berfu, Dilbaz Serdar, Kaplanoğlu Iskender, Dilbaz Berna
Department of In Vitro Fertilization, Etlik Zübeyde Hanım Maternity & Women's Health Teaching Research Hospital, Ankara, Turkey.
J Turk Ger Gynecol Assoc. 2014 Aug 8;15(3):144-8. doi: 10.5152/jtgga.2014.13047. eCollection 2014.
To determine if body mass index has an effect on the outcome of in vitro fertilization in patients with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation.
The study included 337 cycles. Patients were stratified into the following 3 groups: normal weight, overweight, and obese. The primary outcome measures were response to ovarian hyperstimulation, the fertilization rate, the implantation rate, and the clinical and ongoing pregnancy rates.
Total gonadotropin consumption increased, and the number of retrieved oocytes decreased as the body mass index increased. The implantation rate and clinical pregnancy rate were similar in all 3 groups. In response to the mid-luteal long protocol, the cycle cancellation rate was lower and the number of retrieved oocytes was higher in the overweight and obese groups, as compared to the antagonist protocol.
The body mass index did not affect the outcome of in vitro fertilization in women with polycystic ovary syndrome. Additional research is required to better understand the role of stimulation protocols on the cycle outcome.
确定体重指数对接受控制性卵巢刺激的多囊卵巢综合征患者体外受精结局是否有影响。
该研究纳入337个周期。患者被分为以下3组：正常体重、超重和肥胖。主要结局指标为对卵巢刺激的反应、受精率、着床率以及临床妊娠率和持续妊娠率。
随着体重指数增加，促性腺激素总用量增加，而获卵数减少。3组的着床率和临床妊娠率相似。对于黄体中期长效方案，与拮抗剂方案相比，超重和肥胖组的周期取消率更低，获卵数更多。
体重指数不影响多囊卵巢综合征女性的体外受精结局。需要进一步研究以更好地了解刺激方案对周期结局的作用。
