阿托品对离体灌注大鼠肝脏胆汁流量及3H-哇巴因胆汁排泄的影响。

Effect of atropine on bile flow and biliary excretion of 3H-ouabain in the isolated perfused rat liver.

作者信息

Nevasaari K, Alakare B, Kärki N T

出版信息

Pharmacology. 1977;15(1):55-64. doi: 10.1159/000135848.

Abstract

Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative biliary elimination of ouabain was not affected. Atropine choleresis caused an increase in the erythritol clearance rate and a reduction in the bile to plasma ratios of erythritol as compared to the controls. The results suggest that the choleresis induced by atropine is not entirely of canalicular origin but possibly reabsorption mechanisms in the bile ducts or ductules are also involved.

摘要

在离体灌注大鼠肝脏中，研究了阿托品（4×10⁻⁴M）产生的利胆作用对³H-哇巴因胆汁排泄及¹⁴C-赤藓醇胆汁清除率的影响。阿托品引起的胆汁流量增加与胆汁中³H-哇巴因水平降低相关。哇巴因的累积胆汁排泄未受影响。与对照组相比，阿托品利胆使赤藓醇清除率增加，赤藓醇的胆汁与血浆比值降低。结果表明，阿托品诱导的利胆作用并非完全源于胆小管，胆管或小胆管中的重吸收机制可能也参与其中。