Karege F, Bovier P, Hilleret H, Gaillard J M
Service de la Recherche Biologique et de Psychopharmacologie Clinique, Institutions Universitaires de Psychiatrie-Genève (IUPG), Switzerland.
J Affect Disord. 1993 Jul;28(3):211-7. doi: 10.1016/0165-0327(93)90107-u.
This report was undertaken to test the noradrenergic deficiency hypothesis of depression and the postulated increase in noradrenergic activity associated to anxiety states. A possible dual effect of both depression and anxiety on total plasma MHPG levels was hypothesized and assessed in anxious and non-anxious depressed patients. The findings show a decrease in plasma MHPG levels in depressed patients whatever their degree of anxiety. There was no difference in total plasma MHPG levels either between anxious and non-anxious depressed patients or between low and high anxiety to depression ratio (ADR) depressed patients. Following antidepressant drug-treatment, a decrease in plasma MHPG was found. A positive correlation between the drug-induced decrease in NA activity and the severity of depression was observed, and suggested a relationship between the severity of depression and the instability of the NA system. No correlation between the drug-induced decrease in plasma MHPG and the degree of anxiety was found. The results do not suggest out an effect of anxiety on total plasma MHPG levels in depressed patients.
本报告旨在检验抑郁症的去甲肾上腺素能缺乏假说以及与焦虑状态相关的去甲肾上腺素能活性假定增加。研究假设并评估了抑郁和焦虑对血浆总3-甲氧基-4-羟基苯乙二醇（MHPG）水平的可能双重影响，该研究对象为焦虑和非焦虑的抑郁症患者。研究结果显示，无论抑郁症患者的焦虑程度如何，其血浆MHPG水平均会降低。焦虑和非焦虑抑郁症患者之间，以及低焦虑与高焦虑抑郁比（ADR）抑郁症患者之间，血浆总MHPG水平均无差异。抗抑郁药物治疗后，血浆MHPG水平下降。观察到药物引起的去甲肾上腺素（NA）活性降低与抑郁严重程度之间呈正相关，这表明抑郁严重程度与NA系统的不稳定性之间存在关联。未发现药物引起的血浆MHPG降低与焦虑程度之间存在相关性。研究结果并未表明焦虑对抑郁症患者血浆总MHPG水平有影响。
