Singh R B, Niaz M A, Ghosh S, Singh R, Rastogi S S
Medical Hospital and Research Center, Moradabad, India.
J Am Coll Nutr. 1993 Jun;12(3):255-61. doi: 10.1080/07315724.1993.10718307.
The effects of antioxidant-rich foods as adjuncts to a prudent diet were compared for 12 weeks in a randomized, single-blind and controlled trial in 204 (group A) and 202 (group B) patients with acute myocardial infarction. There was a significant decrease in cardiac end points in group A compared to group B (37 vs 58, p < 0.01) after 12 weeks. Within intervention group A, those 108 patients with greater adherence to the intervention program showed a greater reduction in cardiac end points (14 vs 58, p < 0.001), and a significant decrease in total mortality (6 vs 28, p < 0.001), including cardiac mortality (6 vs 25, p < 0.01) compared to group B. Underlying these beneficial effects, antioxidant-rich foods caused a significantly smaller rise in lactate dehydrogenase (LDH) cardiac enzyme in group A than in group B (427.8 vs 561.6 IU/dL), indicating that the protective influence of such a diet may be observed within 1 week. The subset of group A patients showing reduction in mortality also had a lesser rise in LDH and greater reduction in blood lipids, blood glucose and blood pressures. Antioxidant-rich foods also caused a significant decrease in blood lipids with a lower decrease in high-density lipoprotein cholesterol in group A than in group B. Assay of serum level of antioxidants and long-term follow-up may confirm our observations.
在一项针对204例（A组）和202例（B组）急性心肌梗死患者的随机、单盲对照试验中，比较了富含抗氧化剂的食物作为合理饮食辅助手段的效果，为期12周。12周后，与B组相比，A组的心脏终点事件显著减少（37例对58例，p<0.01）。在干预A组中，那些对干预方案依从性较高的108例患者，其心脏终点事件的减少更为显著（14例对58例，p<0.001），总死亡率显著降低（6例对28例，p<0.001），包括心脏死亡率（6例对25例，p<0.01），与B组相比。在这些有益效果的背后，富含抗氧化剂的食物使A组乳酸脱氢酶（LDH）心脏酶的升高幅度明显小于B组（427.8 IU/dL对561.6 IU/dL），这表明这种饮食的保护作用可能在1周内就可观察到。A组中死亡率降低的患者亚组，其LDH升高幅度也较小，血脂、血糖和血压的降低幅度更大。富含抗氧化剂的食物还使血脂显著降低，A组高密度脂蛋白胆固醇的降低幅度低于B组。抗氧化剂血清水平的检测和长期随访可能会证实我们的观察结果。
