J Am Geriatr Soc. 1993 Sep;41(9):915-22. doi: 10.1111/j.1532-5415.1993.tb06755.x.
To determine the effectiveness of terodiline, a drug with calcium antagonist and anticholinergic properties, on the frequency of incontinence in older non-institutionalized women.
Randomized, placebo-controlled, parallel-group, double-blind trial.
Twelve outpatient clinics across the United States affiliated with programs in either geriatrics, gynecology, or urology.
Ninety-eight women, age 60 or older, with symptoms of urge incontinence and self-reported frequency of incontinence four or more times per week and involuntary bladder contractions on dual-channel water cystometry.
Self-reported urinary frequency, urgency, number of incontinence episodes, and number of heavily soaked pads.
Eighty-one women, average age 71, completed the trial, 40 in the active drug group, 41 in the placebo group. Incontinence frequency and the number of heavily soaked pads were reduced in the active drug group by 64% and 55%, respectively, and by 21% (P = 0.002) and 9% (P = 0.04) in the placebo group. No patients dropped out due to adverse effects. An intention-to-treat analysis of all 98 patients yielded the same conclusion.
Terodiline is highly effective in reducing incontinence in older, noninstitutionalized women with urge incontinence. Because of its potential association with polymorphic ventricular tachycardia (torsades de pointes), terodiline must undergo further testing to define its safety before it can be recommended for clinical use in the incontinent geriatric population.
确定具有钙拮抗剂和抗胆碱能特性的药物特罗地林对老年非机构化女性尿失禁频率的疗效。
随机、安慰剂对照、平行组、双盲试验。
美国12家门诊诊所，隶属于老年医学、妇科或泌尿科项目。
98名60岁及以上的女性，有急迫性尿失禁症状，自我报告每周尿失禁频率为4次或更多次，并且在双通道水囊膀胱测压时有膀胱不自主收缩。
自我报告的排尿频率、尿急、尿失禁发作次数以及湿透的厚垫数量。
81名女性（平均年龄71岁）完成了试验，40名在活性药物组，41名在安慰剂组。活性药物组的尿失禁频率和湿透的厚垫数量分别降低了64%和55%，安慰剂组分别降低了21%（P = 0.002）和9%（P = 0.04）。没有患者因不良反应退出。对所有98名患者进行的意向性分析得出了相同的结论。
特罗地林在减少患有急迫性尿失禁的老年非机构化女性的尿失禁方面非常有效。由于其与多形性室性心动过速（尖端扭转型室速）的潜在关联，特罗地林在被推荐用于老年尿失禁患者的临床使用之前，必须进行进一步测试以确定其安全性。
