Hellström A L, Hjälmås K, Jodal U
Department of Paediatric Surgery, University of Gothenburg, Sweden.
Br J Urol. 1989 Apr;63(4):358-62. doi: 10.1111/j.1464-410x.1989.tb05217.x.
A double-blind study of terodiline compared with placebo was performed in 58 children aged 6 to 14 years with urgency or urge incontinence. All had an unstable bladder at cystometry. A bladder regimen was emphasised during the study. Continence was improved according to micturition charting and a pad test in both groups. Terodiline at 25 mg/day, however, gave significantly better results than placebo. In patients with a subnormal bladder capacity (less than or equal to 150 ml), a significant increase in capacity was recorded on cystometry during medication with terodiline but not with placebo. The improved continence seen in the placebo group was probably due to the non-specific bladder training achieved by the child's increased awareness and adult involvement during treatment. The even better results attained in the terodiline group shows this drug to be a valuable adjunct to a bladder regimen in children with urge incontinence, particularly since no important adverse effects were noted during an 8-week period.
对58名6至14岁有尿急或急迫性尿失禁的儿童进行了一项将特罗地林与安慰剂对比的双盲研究。所有患儿膀胱测压时膀胱均不稳定。研究期间强调了膀胱训练方案。根据排尿记录和尿垫试验，两组患儿的尿失禁情况均有改善。然而，每日25毫克的特罗地林组比安慰剂组效果显著更好。膀胱容量低于正常（小于或等于150毫升）的患者，在服用特罗地林而非安慰剂期间，膀胱测压显示膀胱容量显著增加。安慰剂组尿失禁情况的改善可能是由于治疗期间患儿意识增强及成人参与所实现的非特异性膀胱训练。特罗地林组取得的更好效果表明，该药对于急迫性尿失禁患儿的膀胱训练方案是一种有价值的辅助药物，特别是因为在8周期间未观察到重要的不良反应。
