Ochs A, Sellinger M, Haag K, Nöldge G, Herbst E W, Walter E, Gerok W, Rössle M
Department of Internal Medicine, Medizinische Universitätsklinik, Freiburg, Germany.
J Hepatol. 1993 Jun;18(2):217-25. doi: 10.1016/s0168-8278(05)80249-1.
Budd-Chiari syndrome is characterized by splanchnic congestion due to obstruction of the hepatic venous outflow. A variety of treatment modalities have limited applicability due to their invasive nature, complications or low effectivity. The transjugular intrahepatic portosystemic stent-shunt (TIPS) offers a new treatment by creating an intraparenchymal duct between a main branch of the portal vein and hepatic vein i.e. the intrahepatic part of the inferior vena cava. This paper describes the treatment of two patients with fulminant and subacute Budd-Chiari syndrome treated 2 days and 2 months after the onset of clinical symptoms. It demonstrates that TIPS is a feasible treatment of Budd-Chiari syndrome that restores splanchnic blood flow, reduces collateral circulation and ascites and provides sufficient time to allow for elective liver transplantation, if indicated. Further studies are required to evaluate the effect of TIPS on liver function and survival.
布加综合征的特征是肝静脉流出道梗阻导致内脏充血。由于其侵入性、并发症或低有效性，多种治疗方式的适用性有限。经颈静脉肝内门体分流术（TIPS）通过在门静脉主分支和肝静脉（即下腔静脉肝内部分）之间建立肝实质内通道提供了一种新的治疗方法。本文描述了对两名暴发性和亚急性布加综合征患者在临床症状出现后2天和2个月进行治疗的情况。结果表明，TIPS是治疗布加综合征的一种可行方法，可恢复内脏血流，减少侧支循环和腹水，并在必要时为择期肝移植争取足够时间。需要进一步研究来评估TIPS对肝功能和生存率的影响。
