Gonzalez-Crussi F, Lee S C, McKinney M
Plast Reconstr Surg. 1977 Mar;59(3):411-7. doi: 10.1097/00006534-197703000-00017.
Two cases of congenital localized gigantism are described. They illustrate a form of segmental limb disproportion, characterized pathologically by an excessive linear growth of the skeletal structures and by soft tissue lipomatosis. The gigantism was confined to bones of the right great toe and adjacent metatarsus in one case; it affected the long bones of a lower extremity in the second case. Case 2, followed for over 7 years, developed a fibrovascular hamartomatous neoplasm of rapid growth and some cytological atypia in infancy--but this was well controlled by conservative surgery. This type of gigantism of the limb appears to be compatible with a normal life expectancy, and it is conceptually useful to distinguish it from hemihypertrophy. The number of cases reported is insufficient to support a significant association of gigantism with malignant tumors or with other life-jeopardizing anomalies.
本文描述了两例先天性局限性巨大症病例。它们展现了一种节段性肢体不对称的形式，其病理特征为骨骼结构的过度线性生长以及软组织脂肪瘤病。在其中一例中，巨大症局限于右大脚趾和相邻的跖骨；在第二例中，它影响了下肢的长骨。第二例随访超过7年，在婴儿期出现了快速生长且有一些细胞学异型性的纤维血管错构瘤性肿瘤——但通过保守手术得到了良好控制。这种肢体巨大症似乎与正常预期寿命相符，并且在概念上将其与半侧肥大区分开来是有用的。报告的病例数量不足以支持巨大症与恶性肿瘤或其他危及生命的异常之间存在显著关联。
