Chahar O P, Bundella B, Chahar C K, Purohit M
Department of Paediatrics, SP Medical College, Bikaner.
J Indian Med Assoc. 1993 Apr;91(4):86-7.
Measurements of protein to creatinine ratios in single voided urine samples were compared with 24 hour urinary protein excretion for quantification of proteinuria in 20 healthy control and 30 patients of various renal diseases. The range of proteinuria in study group was 1.46-6.0 g/day and renal function was stable in all the cases. An excellent correlation was found between the results obtained by this method and those from the standard 24 hours urine collection method in healthy controls (r = 0.99) and in patients with renal disease (r = 0.98). In our study urinary protein-creatinine ratio in control group was less than 0.2 in all cases and in study group was more than 3.0 except in one. The results of the present study indicate that the random urine protein-creatinine ratio is highly reliable test for quantification of proteinuria in children and has obvious advantage in term of time, cost and patients convenience.
在20名健康对照者和30名患有各种肾脏疾病的患者中，对单次晨尿样本中的蛋白质与肌酐比值进行了测量，并与24小时尿蛋白排泄量进行比较，以定量蛋白尿。研究组的蛋白尿范围为1.46 - 6.0克/天，所有病例的肾功能均稳定。在健康对照者（r = 0.99）和肾病患者（r = 0.98）中，该方法获得的结果与标准24小时尿液收集方法获得的结果之间发现了极好的相关性。在我们的研究中，对照组的尿蛋白 - 肌酐比值在所有病例中均小于0.2，而研究组除一例外在所有病例中均大于3.0。本研究结果表明，随机尿蛋白 - 肌酐比值是定量儿童蛋白尿的高度可靠检测方法，在时间、成本和患者便利性方面具有明显优势。
