Datta C, Dutta S K, Chaudhuri A
Department of Pathology and Bacteriology, RG Kar Medical College, Calcutta.
J Indian Med Assoc. 1993 Jun;91(6):146-8.
Balanitis xerotica obliterans consisting of 52 cases had been studied in the present series. This disease entity is an insidious sclerosing disease of unknown aetiology, affecting mainly the skin and mucous membrane of glans, prepuce and sometimes the fossa navicularis urethrae or even terminal urethra. Atrophic white patches on external genitalia and obstructive uropathy are two common presenting features. It has been classified as local form of lichen sclerosus et atrophicus. Poor local hygiene, circumcision and association of auto-immune diseases like vitiligo are responsible as suggested in this study. Routine tests detected associated cystitis in 8 cases, haematuria in 4 cases, non-reactive VDRL in all cases and impaired glucose tolerance in 5 cases. Immunoglobulin profile (39 cases) showed altered pattern, suggesting some chronic antigenic stimulation. Out of 33 cases where biopsy done, histologically proved typical balanitis xerotica obliterans was found in 19 cases. Malignant change was noted in one case only. Circumcision and dilatation offered temporary relief.
本研究系列共对52例闭塞性干燥性龟头炎患者进行了研究。该疾病实体是一种病因不明的隐匿性硬化性疾病，主要影响龟头、包皮的皮肤和黏膜，有时也累及舟状窝尿道甚至尿道末端。外生殖器萎缩性白斑和梗阻性尿路病是两个常见的临床表现。它已被归类为局限性硬化萎缩性苔藓。本研究表明，局部卫生状况差、包皮环切术以及白癜风等自身免疫性疾病的关联是其发病原因。常规检查发现8例伴有膀胱炎，4例有血尿，所有病例梅毒血清学试验（VDRL）均无反应，5例糖耐量受损。免疫球蛋白谱（39例）显示模式改变，提示存在某种慢性抗原刺激。在33例行活检的病例中，组织学证实19例为典型的闭塞性干燥性龟头炎。仅1例发现有恶性变。包皮环切术和扩张术可提供暂时缓解。
