Reynolds A J, Lawrence C M, Jahoda C A
Department of Biological Sciences, University of Durham, U.K.
J Invest Dermatol. 1993 Oct;101(4):634-8. doi: 10.1111/1523-1747.ep12366095.
Isolated human hair follicle germinative epidermal cells were observed in vitro for the first time. When cultured alone, this small, round, novel cell type did not grow, divide, take on an outer root sheath-type appearance, or display any obvious signs of epidermal differentiation. We have previously described comparable cells from rat vibrissa follicles. However, in combination with human hair follicle dermal papilla populations, the germinative epidermal cells were stimulated into proliferative and complex interactive behaviors. This included the formation of composite organotypic structures containing not only impressively intact basement membrane, but also the hair-specific form, glassy membrane.
首次在体外观察到分离的人毛囊生发表皮细胞。单独培养时，这种小的、圆形的新型细胞类型不生长、不分裂，不呈现外根鞘样外观，也不显示任何明显的表皮分化迹象。我们之前描述过来自大鼠触须毛囊的类似细胞。然而，与人类毛囊真皮乳头群体共同培养时，生发表皮细胞被刺激进入增殖和复杂的相互作用行为。这包括形成复合器官样结构，该结构不仅含有令人印象深刻的完整基底膜，还含有毛发特有的透明膜。
