累及脑部的成人组织细胞增多症X的临床病理研究

Hasegawa K, Mitomi T, Kowa H, Motoori T, Yagisita S

Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.

J Neurol Neurosurg Psychiatry. 1993 Sep;56(9):1008-12. doi: 10.1136/jnnp.56.9.1008.

Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.

累及中枢神经系统的成人组织细胞增多症X导致进行性痉挛性截瘫。诊断通过免疫反应性抗S100蛋白抗体染色以及皮肤病变活检标本中存在Birbeck颗粒来做出。神经病理学检查显示，整个中枢神经系统中含S-100的组织细胞样细胞和反应性星形胶质细胞大量增殖并浸润。