Mehta P D, Dalton A J, Mehta S P, Percy M E, Sersen E A, Wisniewski H M
Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
J Neurol Sci. 1993 Jul;117(1-2):186-91. doi: 10.1016/0022-510x(93)90172-u.
IgG subclasses were measured in sera from 33 persons with Down syndrome (DS) (mean age 55 +/- 7 years) and 33 age- and sex-matched control individuals using a mouse monoclonal antibody based sandwich enzyme linked immunosorbent assay. Significantly higher levels of IgG1 and IgG3 and lower levels of IgG2 and IgG4 subclasses were found in the DS group compared to the control individuals. The higher levels of IgG1 and IgG3 subclasses found in DS persons were consistent with those seen in patients with autoimmune diseases and chronic viral infections; the lower levels of IgG2 and IgG4 subclasses were consistent with those seen in patients with recurrent infections. Our findings are similar to those reported in children with DS. We speculate that the subclass levels may have little or no relationship to the development of brain lesions typical of Alzheimer disease in older persons with DS. There were no significant differences between the levels of IgG subclasses of persons with DS showing signs of dementia of the Alzheimer type compared to those without such manifestations.
采用基于小鼠单克隆抗体的夹心酶联免疫吸附测定法，对33名唐氏综合征（DS）患者（平均年龄55±7岁）和33名年龄及性别匹配的对照个体的血清进行了IgG亚类检测。与对照个体相比，DS组中IgG1和IgG3水平显著升高，而IgG2和IgG4亚类水平降低。DS患者中发现的较高水平的IgG1和IgG3亚类与自身免疫性疾病和慢性病毒感染患者中所见的情况一致；较低水平的IgG2和IgG4亚类与反复感染患者中所见的情况一致。我们的发现与报道的患有DS的儿童的发现相似。我们推测，在患有DS的老年人中，亚类水平可能与典型的阿尔茨海默病脑损伤的发展关系不大或没有关系。与没有此类表现的DS患者相比，表现出阿尔茨海默型痴呆迹象的DS患者的IgG亚类水平没有显著差异。
