唐氏综合征患儿群体中IgG亚类的血清浓度：与兄弟姐妹及普通人群的比较研究

IgG subclasses serum concentrations in a population of children with Down syndrome: comparative study with siblings and general population.

作者信息

Barradas C, Charlton J, MendoCa P, Lopes A I, Palha M, Trindade J C

机构信息

University Clinic or Paediatrics. Hospital of Santa Maria. Lisboa. Portugal.

出版信息

Allergol Immunopathol (Madr). 2002 Mar-Apr;30(2):57-61. doi: 10.1016/s0301-0546(02)79091-5.

DOI:10.1016/s0301-0546(02)79091-5

Abstract

Serum total IgG and subclasses were determined in three different groups of children: with Down syndrome, their siblings and general pediatric population. Several cases of IgG2 and IgG4 deficiency were identified, predominantly in children with Down syndrome. The differences, considering three age groups, were statistically significant for both groups in relation to the general population group, with an increase of IgG1 and IgG3 and a decrease in serum concentrations of IgG2 and IgG4. Down syndrome children and their siblings tend o have a similar variation of the IgG4 serum concentration levels (P < 0.05). The mechanisms of this concordance are not well understood. The results point out that an adequate strategy to improve the immune status of Down syndrome children could have a positive manifestation in the immune profile of their brothers.

摘要

在三组不同的儿童中测定了血清总IgG及其亚类：唐氏综合征患儿、他们的兄弟姐妹以及普通儿科人群。发现了几例IgG2和IgG4缺乏的病例，主要见于唐氏综合征患儿。考虑到三个年龄组，与普通人群组相比，这两组在IgG1和IgG3升高以及IgG2和IgG4血清浓度降低方面的差异具有统计学意义。唐氏综合征患儿及其兄弟姐妹的IgG4血清浓度水平往往有相似的变化（P<0.05）。这种一致性的机制尚不清楚。结果指出，改善唐氏综合征患儿免疫状态的适当策略可能对其兄弟姐妹的免疫状况产生积极影响。