Steen R G, Kromhout-Schiro S, Graham M M
Department of Radiology, University of Washington School of Medicine, Seattle 98195.
J Neurooncol. 1993 Apr;16(1):81-7. doi: 10.1007/BF01324839.
The relationship between tumor perfusion and edema was analyzed, with edema characterized as tumor wet/dry weight ratio. Perfusion of subcutaneous 9L gliosarcoma was measured by injection of 133Xe in saline into the tumor core, followed by gamma camera imaging of 133Xe washout kinetics. A significant inverse correlation was found between edema and tumor perfusion (p < 0.0002), suggesting that edema can limit tumor perfusion, perhaps through a mechanism of increased interstitial fluid pressure. The perfusion rate of highly edematous tumors was reduced to less than 10% of the perfusion rate of less edematous tumors (p < 0.001). It was also found that tumor edema increased significantly with increasing tumor volume (p < 0.001), which could account for the finding that perfusion declined significantly with increasing tumor volume (p < 0.02). These findings are potentially important because it is possible to quantify tumor edema in vivo, with millimeter resolution, using 1H magnetic resonance imaging (MRI). Thus MRI may provide a non-invasive technique for characterizing tumor perfusion or tumor drug delivery.
分析了肿瘤灌注与水肿之间的关系，水肿以肿瘤湿重/干重比为特征。通过将盐水中的133Xe注入肿瘤核心，随后对133Xe洗脱动力学进行γ相机成像，测量皮下9L胶质肉瘤的灌注。发现水肿与肿瘤灌注之间存在显著的负相关（p < 0.0002），这表明水肿可能通过增加间质液压力的机制限制肿瘤灌注。高度水肿肿瘤的灌注率降低至水肿较轻肿瘤灌注率的10%以下（p < 0.001）。还发现肿瘤水肿随肿瘤体积增加而显著增加（p < 0.001），这可以解释随着肿瘤体积增加灌注显著下降的现象（p < 0.02）。这些发现可能具有重要意义，因为使用1H磁共振成像（MRI）可以在体内以毫米分辨率量化肿瘤水肿。因此，MRI可能提供一种用于表征肿瘤灌注或肿瘤药物递送的非侵入性技术。
