van der Lugt J J, van Heerden J
Section of Pathology, Onderstepoort Veterinary Institute, Republic of South Africa.
J S Afr Vet Assoc. 1993 Jun;64(2):82-8.
The histological and ultrastructural lesions of sheep (n = 5) with experimentally-induced vermeersiekte (Geigeria ornativa O. Hoffm. poisoning) were studied. Histological changes in the muscles of the skeletal system, diaphragm and oesophagus comprised hypertrophy and vacuolation of myofibres. In 2 sheep, foci of myocardial degeneration and necrosis were present. No microscopical changes were detected in the central nervous system and in peripheral nerves of the oesophagus and the hind limb. Ultrastructural alterations in the myocardium, semimembranosus muscle and oesophagus were characterised by concurrent myofibrillar degeneration and mitochondrial swelling. The earliest myofibrillar change appeared to be loss of the thick filaments followed by fragmentation and disorganisation and eventually by lysis of central myofibrils. Focal thickening, fragmentation and clumping of Z-band material and dissociation and fragmentation of intercalated discs accompanied the myofibrillar and mitochondrial alterations.
对5只经实验诱发患vermeersiekte（奥氏盖泽草中毒）的绵羊的组织学和超微结构损伤进行了研究。骨骼系统、膈肌和食管肌肉的组织学变化包括肌纤维肥大和空泡化。2只绵羊出现心肌变性和坏死灶。在中枢神经系统以及食管和后肢的周围神经中未检测到微观变化。心肌、半膜肌和食管的超微结构改变的特征是肌原纤维变性和线粒体肿胀同时出现。最早的肌原纤维变化似乎是粗肌丝丢失，随后是断裂和紊乱，最终是中央肌原纤维溶解。Z带物质的局灶性增厚、断裂和聚集以及闰盘的解离和断裂伴随着肌原纤维和线粒体的改变。
