Hydrocortisone and the release of prostaglandins from spleen.
作者信息
Grodzińska L, Dembińska-Kieć A
出版信息
Prostaglandins. 1977 Jan;13(1):125-9. doi: 10.1016/0090-6980(77)90049-1.
PMID:841100
Abstract
An infusion of noradrenaline (1 mug/ml/min) released a PGE-like substance (PGEs) from superfused splenic strips of rabbits and from perfused cat spleen. The release of PGEs from rabbit splenic strips was not inhibited by the treatment of strips with hydrocortisone (40-150 mug/ml), but it was completely abolished in strips obtained from animals pretreated with hydrocortisone (1 mg/kg). The release of PGEs from the perfused cat spleen was reduced by hydrocortisone and abolished by indomethacin. It is concluded that the route of administration of hydrocortisone is essential for an appearance of its inhibitory effect on the PG release.
摘要
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Hydrocortisone and the release of prostaglandins from spleen.
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引用本文的文献
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Stimulation of prostaglandin E2-synthesis by noradrenaline in primary cell cultures from rabbit splenic pulpa is mediated by atypical alpha-adrenoceptors.去甲肾上腺素对兔脾髓原代细胞培养物中前列腺素E2合成的刺激作用是由非典型α-肾上腺素能受体介导的。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb;316(1):1-7. doi: 10.1007/BF00507219.
2
Shortening of the bleeding time in rabbits by hydrocortisone caused by inhibition of prostacyclin generation by the vessel wall.氢化可的松通过抑制血管壁前列环素的生成而使家兔出血时间缩短。
J Clin Invest. 1979 May;63(5):1026-35. doi: 10.1172/JCI109371.
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