前列腺素E2对妊娠兔血管紧张素II心血管反应的影响。
The effect of prostaglandin E2 on the cardiovascular response to angiotensin II in pregnant rabbits.
作者信息
O'Brien P M, Filshie G M, Broughton Pipkin F
出版信息
Prostaglandins. 1977 Jan;13(1):171-81. doi: 10.1016/0090-6980(77)90054-5.
The rise in arterial blood pressure in response to angiotensin II was studied in the last third of pregnancy in rabbits. The response was compared with that of pregnant rabbits during infusion of prostaglandin E2 and F2alpha. Prostaglandin E2 significantly diminished the rise in diastolic pressure in response to angiotensin II. Prostaglandin F2alpha did not alter the response. Intravenous indomethacin elevated the blood pressure and caused an absolute increase in the pressor response. It did not mediate a change in the percentage rise in blood pressure in response to angiotensin II.
在妊娠后期的三分之一阶段，对兔进行了研究，以观察其对血管紧张素II的动脉血压升高反应。将该反应与输注前列腺素E2和F2α期间的妊娠兔反应进行了比较。前列腺素E2显著减弱了对血管紧张素II的舒张压升高反应。前列腺素F2α未改变该反应。静脉注射吲哚美辛使血压升高，并导致升压反应绝对增加。它并未介导对血管紧张素II的血压升高百分比变化。
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