Rh血型结构的分子与遗传分析的最新进展。

Recent advances in molecular and genetic analysis of Rh blood group structures.

作者信息

Colin Y, Cherif-Zahar B, Le Van Kim C, Mouro I, Cartron J P

机构信息

Unité INSERM U76, Institut National de Transfusion Sanguine, Paris, France.

出版信息

J Med Primatol. 1993 Jan;22(1):36-43.

PMID:8411097

Abstract

The Rh antigens are carried by 30-32 kDa integral proteins of the red cell membrane. The Rh locus is composed of two genes: RhD, which encodes the major D antigen and is present only in Rh-positive genomes, and RhCcEe, which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. The D and non-D Rh mRNAs have been cloned. Their sequence homology suggest that the two Rh genes have evolved by duplication of a common ancestor.

摘要

Rh抗原由红细胞膜上30 - 32 kDa的整合蛋白携带。Rh基因座由两个基因组成：RhD，编码主要的D抗原，仅存在于Rh阳性基因组中；RhCcEe，编码Cc和Ee多肽，很可能是通过可变剪接事件实现的。D和非D型Rh mRNA已被克隆。它们的序列同源性表明这两个Rh基因是由一个共同祖先基因复制进化而来的。