Putkonen P, Nilsson C, Hild K, Benthin R, Cranage M, Aubertin A M, Biberfeld G
Department of Immunology, National Bacteriological Laboratory, Stockholm, Sweden.
J Med Primatol. 1993 Feb-May;22(2-3):100-3.
Several groups have reported protection against experimental SIV infection in macaques immunized with a whole inactivated virus vaccine. The aim of the current study was to investigate whether five macaques vaccinated with whole inactivated SIV and previously shown to be protected against challenge with two divergent strains of SIV grown on human cells could resist challenge with a subsequent homologous SIV grown on macaque cells. We show here that this same vaccine did not protect when the challenge virus was grown on primary cells of monkey origin.
有几个研究小组报告称，用全灭活病毒疫苗免疫的猕猴对实验性SIV感染具有保护作用。本研究的目的是调查五只接种了全灭活SIV疫苗且之前已证明对在人细胞上培养的两种不同SIV毒株的攻击具有抵抗力的猕猴，是否能够抵抗随后在猕猴细胞上培养的同源SIV的攻击。我们在此表明，当攻击病毒在猴源原代细胞上培养时，这种相同的疫苗没有起到保护作用。
