营养、免疫与感染：蛋白质 - 能量营养不良中的T淋巴细胞亚群

Nutrition, immunity and infections: T lymphocyte subpopulations in protein--energy malnutrition.

作者信息

Ozkan H, Olgun N, Saşmaz E, Abacioğlu H, Okuyan M, Cevik N

机构信息

Department of Pediatrics, School of Medicine, Dokuz Eylül University, Izmir, Turkey.

出版信息

J Trop Pediatr. 1993 Aug;39(4):257-60. doi: 10.1093/tropej/39.4.257.

DOI:10.1093/tropej/39.4.257

PMID:8411323

Abstract

Protein energy malnutrition (PEM) is one of the most frequent causes of secondary immune deficiency states. Alterations either in cellular or humoral immune mechanisms increase the susceptibility to infections in the malnourished organism. Infections aggravate the interrelationship of malnutrition to immune deficiency and infections, resulting in future adverse effects of malnutrition on humoral and cellular immune systems, IgG, IgM, IgA, C3, and T lymphocyte subpopulations were identified in 29 patients with PEM and 15 healthy infants serving as the control group, ranging between 3 and 24 months of age. Patients with PEM demonstrated elevated levels of IgG, IgM and IgA when compared to the control group (P < 0.01, P < 0.01, P < 0.01), C3 levels were significantly lower than the values of the control group (P < 0.01).

摘要

蛋白质能量营养不良（PEM）是继发性免疫缺陷状态最常见的原因之一。细胞免疫或体液免疫机制的改变会增加营养不良机体对感染的易感性。感染会加剧营养不良与免疫缺陷及感染之间的相互关系，导致营养不良对体液和细胞免疫系统、IgG、IgM、IgA、C3和T淋巴细胞亚群产生未来的不良影响。对29例PEM患儿和15例年龄在3至24个月的健康婴儿作为对照组进行了IgG、IgM、IgA、C3和T淋巴细胞亚群的检测。与对照组相比，PEM患儿的IgG、IgM和IgA水平升高（P<0.01，P<0.01，P<0.01），C3水平显著低于对照组（P<0.01）。