[Recent advances in lipoprotein metabolism].

Recent advances in lipoprotein metabolism were reviewed. The scavenger receptor for acetyl-LDL cloned by Kodama et al. was immunohistochemically demonstrated to exist in the human atherosclerotic lesions. LDL-receptor related protein (LRP) and VLDL receptor which would recognize apoE but not apoB have been recently cloned. Transgenic mice expressing high levels of apolipoproteins such as apoA-I and apoE or apolipoprotein deficient mice produced by gene targetting technique are providing important information on the function of apolipoproteins.