Miyazaki A, Horiuchi S
Biochemistry II, Kumamoto University School of Medicine.
Nihon Rinsho. 1993 Aug;51(8):1954-60.
Recent advances in lipoprotein metabolism were reviewed. The scavenger receptor for acetyl-LDL cloned by Kodama et al. was immunohistochemically demonstrated to exist in the human atherosclerotic lesions. LDL-receptor related protein (LRP) and VLDL receptor which would recognize apoE but not apoB have been recently cloned. Transgenic mice expressing high levels of apolipoproteins such as apoA-I and apoE or apolipoprotein deficient mice produced by gene targetting technique are providing important information on the function of apolipoproteins.
综述了脂蛋白代谢的最新进展。小田等克隆的乙酰化低密度脂蛋白清除受体经免疫组织化学证实存在于人类动脉粥样硬化病变中。最近已克隆出能识别载脂蛋白E但不能识别载脂蛋白B的低密度脂蛋白受体相关蛋白（LRP）和极低密度脂蛋白受体。通过基因靶向技术产生的表达高水平载脂蛋白如载脂蛋白A-I和载脂蛋白E的转基因小鼠或载脂蛋白缺陷小鼠，正在为载脂蛋白的功能提供重要信息。
