抗惊厥药物对兔体内Δ⁹-四氢大麻酚诱发癫痫发作的拮抗作用。
Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.
作者信息
Consroe P, Martin P, Eisenstein D
出版信息
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):1-13.
PMID:841172
Abstract
A population of New Zealand White rabbits exhibit behavioral convulsions when given low doses of psychoactive cannabinoids of marijuana. Carbamazepine, diazepam and phenytoin were most effective in blocking these convulsions caused by delta9tetrahydrocannabinol (delta9THC). Phenobarbital and ethosuximide also blocked convulsions but only at toxic doses. Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC.
摘要
一群新西兰白兔在给予低剂量大麻的精神活性大麻素时会出现行为性惊厥。卡马西平、地西泮和苯妥英在阻断由δ9 - 四氢大麻酚（δ9THC）引起的这些惊厥方面最有效。苯巴比妥和乙琥胺也能阻断惊厥，但仅在中毒剂量时有效。大麻二酚在与δ9THC同时给药时可有效阻断惊厥，但在δ9THC之前给药则无效。
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