Brill E
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):73-84.
The in vitro metabolic N-oxidation of 1- and 1-napthylamine, 4-biphenylamine, 2-fluorenylamine and 3-dibenzolfuranylamine has been investigated with intact dog bladder, whole intact bladder mucosa and microsomes prepared from this tissue. Very low levels of metabolic N-oxidation of these carcinogenic amines were detected with these tissue preparations using ferrihemoglobin formation in dog erythrocytes. No N-oxidation by these tissue preparations was observed using gas-liquid chromatography. The concentrations of the N-oxidized metabolites observed in the urine of dogs in vivo exposed to thse amines suggests that N-oxidation takes place predominately in the liver and that the bladder plays, at most, a minor role in the formation of these presumed proximate urinary carcinogens.
已使用完整的犬膀胱、完整的膀胱黏膜以及从该组织制备的微粒体，对1-萘胺、1-萘胺、4-联苯胺、2-芴胺和3-二苯并呋喃胺的体外代谢N-氧化进行了研究。使用犬红细胞中的高铁血红蛋白形成，通过这些组织制剂检测到这些致癌胺的代谢N-氧化水平非常低。使用气液色谱法未观察到这些组织制剂的N-氧化。在体内暴露于这些胺的犬尿液中观察到的N-氧化代谢物浓度表明，N-氧化主要发生在肝脏中，而膀胱在这些假定的直接尿致癌物的形成中至多起次要作用。
