Brill E, Radomski J L
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):85-94.
The effect of L-ascorbic acid on the in vivo metabolic N-oxidation of the bladder carcinogen 4-biphenylamine has been investigated in the dog. Gas chromatographic analysis of the urines of dogs receiving concomitant oral doses of L-ascorbic acid and 4-biphyenylamine showed no significant difference in the N-oxidized metabolites when compared to dogs receiving arylamine alone. The results indicate that pretreatment with large doses of L-ascorbic acid has no effect on the metabolic N-oxidation of 4-biphenylamine or on the urinary concentration of these metabolites. The failure of L-ascrobic acid to lower the urinary concentration of these presumed proximate urinary carcinogens casts doubt on its efficacy in bladder tumor prophylaxis.
已在犬类中研究了L-抗坏血酸对膀胱致癌物4-联苯胺体内代谢性N-氧化的影响。对同时口服L-抗坏血酸和4-联苯胺的犬类尿液进行气相色谱分析，结果显示，与仅接受芳胺的犬类相比，其N-氧化代谢产物并无显著差异。结果表明，大剂量L-抗坏血酸预处理对4-联苯胺的代谢性N-氧化或这些代谢产物的尿液浓度均无影响。L-抗坏血酸未能降低这些假定的近端尿液致癌物的尿液浓度，这使其在预防膀胱肿瘤方面的功效受到质疑。
