Segal M B
Sherrington School of Physiology, United Medical School, St. Thomas's Hospital, London, UK.
J Inherit Metab Dis. 1993;16(4):617-38. doi: 10.1007/BF00711896.
The mechanism of formation of extracellular fluid is first described, followed by an explanation of the relation between osmotic force, reflection coefficient and molecular size. The possible mechanism of brain extracellular fluid formation is then proposed in relation to the restriction offered by the blood-brain barrier. The functions and compositions of cerebrospinal fluid (CSF) are then described followed by sections on the process of formation of CSF, the non-electrolytes and proteins in CSF, the drainage mechanisms and protein synthesis by the choroid plexus.
首先描述细胞外液的形成机制,接着解释渗透力、反射系数与分子大小之间的关系。然后,结合血脑屏障所提供的限制,提出脑细胞外液形成的可能机制。随后描述脑脊液(CSF)的功能和成分,接着阐述脑脊液的形成过程、脑脊液中的非电解质和蛋白质、引流机制以及脉络丛的蛋白质合成。