Li Y F, Newton T J, Weisbrodt N W, Moody F G
Department of Surgery, University of Texas Medical School, Houston 77030.
J Surg Res. 1993 Aug;55(2):182-7. doi: 10.1006/jsre.1993.1127.
Intestinal migrating myoelectric complexes (MMC) were studied in rats subjected to common bile duct ligation. Four pairs of bipolar electrodes were implanted on the jejunum and the ileum of 21 rats. Animals were allowed to recover 7 days before electrical recordings were made. Bile duct ligation at the entrance to the duodenum (low) or above the pancreas (high) or sham operation was performed. MMCs were recorded before and 48 and 72 hr after the operation in each animal. MMC intervals were unchanged following high ligation or sham operation. However, 48 hr after low bile duct ligation, the MMC interval (20.6 +/- 2.5 min) was significantly prolonged compared with that before ligation (14.0 +/- 1.2 min). Further prolonged intervals (28.4 +/- 4.2 min) were observed 72 hr after the ligation. There were no significant differences among the slow wave frequencies in any group of animals, being in the range of 34.1 +/- 1.1 to 36.3 +/- 1.0 cycles/min. Thus, the MMC pattern in this rat model may be affected by the development of acute pancreatitis. The mechanism(s) responsible for altering the MMC pattern are not known; however, hepatic biliary secretion alone does not appear to play a primary role.
对接受胆总管结扎的大鼠的肠道移行性肌电复合波（MMC）进行了研究。在21只大鼠的空肠和回肠上植入了四对双极电极。在进行电记录前，让动物恢复7天。在十二指肠入口处（低位）或胰腺上方（高位）进行胆管结扎或进行假手术。在每只动物术后以及术后48小时和72小时记录MMC。高位结扎或假手术后，MMC间隔无变化。然而，低位胆管结扎术后48小时，MMC间隔（20.6±2.5分钟）与结扎前（14.0±1.2分钟）相比显著延长。结扎术后72小时观察到间隔进一步延长（28.4±4.2分钟）。任何一组动物的慢波频率之间均无显著差异，范围为34.1±1.1至36.3±1.0次/分钟。因此，该大鼠模型中的MMC模式可能受急性胰腺炎发展的影响。改变MMC模式的机制尚不清楚；然而，单独的肝胆汁分泌似乎不发挥主要作用。
