Yaacobi Y, Israel A A, Goldberg E P
Biomedical Engineering Center, University of Florida, Gainesville 32611.
J Surg Res. 1993 Oct;55(4):422-6. doi: 10.1006/jsre.1993.1163.
Polyvinylpyrrolidone (PVP) and carboxymethylcellulose (CMC) solutions were evaluated in a rat cecal abrasion model to test the effect of these high-molecular-weight hydrophilic polymer solutions on postoperative adhesion formation when used as tissue precoating solutions. Eleven groups of 5-20 animals each were studied including 25 control animals treated with Ringer's lactate (RL) solution. Animals were reoperated at 2 weeks and adhesions were scored according to a 0-4 grading scale. Tissue coating following cecal abrasion failed to inhibit adhesion formation. However, tissue coating with polymer solutions prior to cecal abrasion significantly reduced the formation of post-operative adhesions. Solutions of 1.5% CMC and 5% of a unique gamma-polymerized PVP in RL exhibited the greatest tissue-protective behavior compared to RL controls (P < 0.002). Both CMC and gamma-PVP solutions warrant further investigation as tissue precoatings to inhibit surgical adhesions.
在大鼠盲肠擦伤模型中评估了聚乙烯吡咯烷酮（PVP）和羧甲基纤维素（CMC）溶液，以测试这些高分子量亲水性聚合物溶液作为组织预涂层溶液时对术后粘连形成的影响。共研究了11组，每组5至20只动物，其中包括25只用乳酸林格氏液（RL）处理的对照动物。在2周时对动物进行再次手术，并根据0至4级评分标准对粘连进行评分。盲肠擦伤后的组织涂层未能抑制粘连形成。然而，在盲肠擦伤前用聚合物溶液进行组织涂层可显著减少术后粘连的形成。与RL对照组相比，1.5% CMC和5%独特的γ-聚合PVP在RL中的溶液表现出最大的组织保护作用（P < 0.002）。CMC和γ-PVP溶液作为抑制手术粘连的组织预涂层都值得进一步研究。
