Back Ja Hoon, Cho Wan Jin, Kim Jun Ho, Park Il Kyu, Kwon Sung Won
Department of Surgery, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-712, Korea.
R&D Center, Genewel Co., Ltd., 37, Sagimakgol-ro 62 beon-gil, Jungwon-gu, Seongnam-si, Gyeonggi-do, 462-738, Korea.
Surg Today. 2016 Apr;46(4):501-8. doi: 10.1007/s00595-015-1186-3. Epub 2015 May 20.
Postsurgical adhesion formation is a concern in every field of surgery. We evaluated the efficacy of hyaluronic acid/sodium alginate-based microparticle anti-adhesive agents (MP) for the prevention of postsurgical adhesion formation in a standardized rabbit model.
To evaluate the anti-adhesion effect, a uterus-abdominal wall abrasion model was created in rabbits. On the surface of the injured uterus, an anti-adhesive agent, Interceed(®) or MP, was applied (positive control and study groups, respectively; n = 10 each). In another group of 10 animals, neither agent was applied (negative control group). The adhesion levels were graded 3 weeks after surgery. Acute and chronic toxicity was also evaluated.
The grade of adhesion was significantly lower in the MP group than in the negative control and positive control groups. No evidence of acute or chronic toxicity induced by this material was found in blood and tissue analysis.
MP shows potential as an effective novel type of resorbable biomaterial to reduce postoperative adhesion. The easy placement and handling of this material make the MP powder attractive as a tissue adhesion barrier.
术后粘连形成是外科学各个领域都关注的问题。我们在标准化兔模型中评估了基于透明质酸/海藻酸钠的微粒抗粘连剂（MP）预防术后粘连形成的效果。
为评估抗粘连效果，在兔身上建立子宫-腹壁擦伤模型。在受伤子宫表面分别应用抗粘连剂Interceed®或MP（分别为阳性对照组和研究组；每组n = 10）。在另一组10只动物中，不应用任何一种试剂（阴性对照组）。术后3周对粘连程度进行分级。还评估了急性和慢性毒性。
MP组的粘连分级显著低于阴性对照组和阳性对照组。在血液和组织分析中未发现该材料诱导急性或慢性毒性的证据。
MP显示出作为一种有效的新型可吸收生物材料来减少术后粘连的潜力。这种材料易于放置和操作，使其作为组织粘连屏障具有吸引力。
