Podwysocki B, Zwoliński J, Szklarz E
Department of Medical Analysis, Medical Academy, Wrocław, Poland.
Mater Med Pol. 1993 Jan-Mar;25(1):13-6.
The determination of total hydroxyproline (Hyp) with separation into protein and non-protein fractions was carried out in 24-hour urine samples of healthy persons, patients with sarcoidosis and patients with interstitial pulmonary fibrosis (i.p.f.). In the group of sarcoidosis Hyp excretion was evaluated taking into account progression of pulmonary changes and disease activity. It was found that total and non-protein Hyp excretion correlated positively in healthy persons as well as in those with sarcoidosis, and interstitial pulmonary fibrosis. An increased excretion of total and non-protein Hyp occurred in 24% of the patients with sarcoidosis while excretion of protein Hyp remained within the normal range. In 30% of the patients with interstitial pulmonary fibrosis increased excretion of total and non-protein Hyp was demonstrated. The excretion of protein Hyp in these patients did not deviate from normal values. The results of our study indicate that determination of total and nonprotein Hyp in urine may be useful in the evaluation of fibrotic changes in the pulmonary diseases mentioned above. However, these parameters are not usefull in differentiation between sarcoidosis and interstitial pulmonary fibrosis.
在健康人、结节病患者和间质性肺纤维化（i.p.f.）患者的24小时尿液样本中，对总羟脯氨酸（Hyp）进行了测定，并将其分为蛋白质和非蛋白质部分。在结节病组中，根据肺部变化的进展和疾病活动情况评估Hyp排泄情况。结果发现，健康人、结节病患者和间质性肺纤维化患者的总Hyp排泄和非蛋白质Hyp排泄呈正相关。24%的结节病患者总Hyp和非蛋白质Hyp排泄增加，而蛋白质Hyp排泄仍在正常范围内。30%的间质性肺纤维化患者显示总Hyp和非蛋白质Hyp排泄增加。这些患者的蛋白质Hyp排泄未偏离正常值。我们的研究结果表明，测定尿液中的总Hyp和非蛋白质Hyp可能有助于评估上述肺部疾病中的纤维化变化。然而，这些参数在区分结节病和间质性肺纤维化方面并无用处。
